Introduction: This study aimed to determine crossmatch-to-transfusion (C/T) ratio and the frequency of acute reactions to transfusion in the blood bank of Shahid Beheshti Hosptial, Hamedan.

Material and Methods: This cross-sectional descriptive study was performed on all transfusions in Shahid Beheshti Hospital, Hamedan, from March 20, 2022 to March 21, 2023. The data source was the previously filled transfusion forms. C/T ratio was calculated by dividing the number of crossmatched units to the number of transfused units. Also, the incidence of fever, chills, pruritus and redness of the skin, skin rash, back pain, hypotension, dyspnea, chest pain, hematuria, and cold sweat during or after transfusion were evaluated. Gender, blood group, and Rh of the blood recepients were also noted.

Results:

Out of 3,630 blood requests, 59.1% were from males and 91.3% Rh-positive. Blood groups were 33.9% A, 21.9% B, 6.9% AB, and 37.7% O. A total of 6,906 units were crossmatched, with 6,611 transfused and 295 unused—mainly from urology, emergency, and other wards. The overall C/T ratio was 1.04, with the highest in Shahrivar (1.21) and lowest in Khordad (1). Common transfusion reactions included chills (0.3%), fever, and dyspnea (0.19%), with no cases of back pain, chest pain, or cold sweat.

Conclusion: It can be conferred that the status of blood usage was good compared to the global standards and there were minimal acute reactions to transfusion. These results could influence transfusion practices or patient safety measures in the hospitals or similar settings.