Human Immunodeficiency Virus (HIV) and Cardiomyopathy: A Systematic Review

Karbasi Afshar, Reza; Jafari Joneidi, Nematollah; Imani, Reza; Fazel, Mozhgan

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	Human Immunodeficiency Virus (HIV) and Cardiomyopathy: A Systematic Review
Article 7, Volume 1, Issue 1, Summer 2013, Page 75-88 PDF (215 K)
Authors
Reza Karbasi Afshar¹; Nematollah Jafari Joneidi²; Reza Imani³; Mozhgan Fazel ²^{, 4}
¹Cardiovascular Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
²Health Research Center, Baqiyatallah University of Medical sciences, Tehran, Iran
³Shahrkord University of Medical Sciences, Shahrkord, Iran
⁴International Teravel Medicine of Iran, Baqiyatallah, Tehran, Iran
Receive Date: 25 September 2013, Accept Date: 25 September 2013
Abstract
Human immunodeficiency virus (HIV) infection has been associated with cardiac disease, including anatomical or functional disturbance to the heart. Cardiomyopathy (CMP) is one of these disturbances that have been associated with high rates of morbidity and mortality. In this review article, several aspects of potential relationships between HIV infection and cardiomyopathy development have been issued. Most studies indicated increased prevalence, incidence and mortality rates for CMP in the HIV infected patients, especially in more advanced grades of the infection. CD4 cell count has been shown to be associated with both incidence and outcome of HIV-related CMP. In children, also similar findings have been observed with high incidence and mortality rates associated with CMP-HIV have been observed. However, prepartum CMP burden in HIV infected mothers was not different than that in HIV-negative ones. However, evidence about the effects of ART on the development and progression of HIV-related CMP was very controversial. While is some studies, no associations have been found in some others, ART has been associated with either a better or worse disease incidence or condition. We propose more studies with prospective approach and large patient populations to be conducted for better understanding of the effects of different ART agents on the incidence and outcome of HIV-related CMP.
Keywords
Human Immunodeficiency Virus; HIV; Cardiomyopathy; Cardiac Dysfunction; Risk factor


References
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