Human Immunodeficiency Virus (HIV) and Cardiomyopathy: A Systematic Review

Authors

1 Cardiovascular Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

2 Health Research Center, Baqiyatallah University of Medical sciences, Tehran, Iran

3 Shahrkord University of Medical Sciences, Shahrkord, Iran

4 International Teravel Medicine of Iran, Baqiyatallah, Tehran, Iran

Abstract

Human immunodeficiency virus (HIV) infection has been associated with cardiac disease, including anatomical or functional disturbance to the heart. Cardiomyopathy (CMP) is one of these disturbances that have been associated with high rates of morbidity and mortality. In this review article, several aspects of potential relationships between HIV infection and cardiomyopathy development have been issued. Most studies indicated increased prevalence, incidence and mortality rates for CMP in the HIV infected patients, especially in more advanced grades of the infection. CD4 cell count has been shown to be associated with both incidence and outcome of HIV-related CMP. In children, also similar findings have been observed with high incidence and mortality rates associated with CMP-HIV have been observed. However, prepartum CMP burden in HIV infected mothers was not different than that in HIV-negative ones. However, evidence about the effects of ART on the development and progression of HIV-related CMP was very controversial. While is some studies, no associations have been found in some others, ART has been associated with either a better or worse disease incidence or condition. We propose more studies with prospective approach and large patient populations to be conducted for better understanding of the effects of different ART agents on the incidence and outcome of HIV-related CMP.

Keywords


World Health Organization Website. Global epidemic and health care response: 2011. Http://apps.who.int/ghodata/?vid=22100. Accessed July 5, 2013
Nakazono T, Jeudy J, White CS. HIV-related cardiac complications: CT and MRI findings. AJR Am J Roentgenol. 2012 Feb;198(2):364-9. doi: 10.2214/AJR.11.6415.
Karbasi-Afshar R, Izadi M. Human Immunodeficiency Virus (HIV) and Acute Coronary Syndrome: A Systematic Review Int J Travel Med Glob Health (in press)
Karbasi-Afshar R, Izadi M. Human Immunodeficiency Virus (HIV) and Stroke Events: A Systematic Review. Int J Travel Med Glob Health (in press)
Ntsekhe M, Mayosi BM. Cardiac manifestations of HIV infection: an African perspective. Nat Clin Pract Cardiovasc Med. 2009 Feb;6(2):120-7. doi:10.1038/ncpcardio1437.
Currie PF, Jacob AJ, Foreman AR, Elton RA, Brettle RP, Boon NA. Heart muscle disease related to HIV infection: prognostic implications. BMJ. 1994 Dec 17;309(6969):1605-7. Reff380