Epidemiology and Characteristics of Extra-ovarian Conditions Mimicking Ovarian Cancer: A 4-Year Assay Among Iranian Women

Document Type : Original Article

Authors

1 Obstetrics and Gynecology Department, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran

2 Student Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran

3 Student Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran

4 Infertility and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

10.15171/ijtmgh.2018.22

Abstract

Introduction: Involving approximately 4% of malignancies in women, ovarian cancer remains one of the most fatal cancers. However, it is important to consider conditions which are not primary ovarian diseases, but mimic their behaviors. In the present study, the epidemiological characteristics of extra-ovarian conditions mimicking ovarian masses are evaluated.
Methods: This cross-sectional study was conducted on patients with a primary diagnosis of ovarian mass who underwent surgery by gynecologists between January 2012 and March 2016. The surgeon’s primary diagnosis and the final histopathology assessment report were evaluated for each patient. In cases where the final histopathology report was not in the spectrum of gynecologic pathology, possible reasons for incompatibility were investigated.
Results: Ultimately, 1876 patients with a mean age of 48.26±15.4 years underwent analysis. Among these patients, 27 (1.4%) had masses of a non-gynecologic origin. The final diagnoses were divided into four main categories: masses with a gastrointestinal origin (55.5%), infectious (18.5%), those with a retroperitoneal origin (18.5%), and embryologic-origin masses (7.4%).
Conclusion: The results suggest that extra-ovarian diseases should be considered in differential diagnoses of patients with a primary diagnosis of ovarian cancer. Furthermore, it was found that metastases from gastrointestinal tract tumors and infectious diseases are the most common pathologies among extra-ovarian conditions.

Keywords

References

  1. Lalooei A, Hashemi SR, Khosravi MH. Histopathological Distribution of Ovarian Masses Occurring After Hysterectomy: A Five-Year Assay in Iranian Patients. Thrita. 2016;5(1):e33131. doi:10.5812/thrita.33131.
  2. Ozat M, Altinkaya SO, Gungor T, et al. Extraovarian conditions mimicking ovarian cancer: a single center experience of 15 years. Arch Gynecol Obstet. 2011;284(3):713-719. doi:10.1007/s00404-010-1705-9
  3. Anuradha S, Webb PM, Blomfield P, et al. Survival of Australian women with invasive epithelial ovarian cancer: a population-based study. Med J Aust. 2014;201(5):283-288. doi:10.5694/mja14.00132.
  4. Baldwin LA, Huang B, Miller RW, et al. Ten-year relative survival for epithelial ovarian cancer. Obstet Gynecol. 2012;120(3):612- 618. doi:10.1097/AOG.0b013e318264f794.
  5. Bjorge T, Lukanova A, Tretli S, et al. Metabolic risk factors and ovarian cancer in the Metabolic Syndrome and Cancer project. Int J Epidemiol. 2011;40(6):1667-1677. doi:10.1093/ije/dyr130.
  6. Previs RA, Kilgore J, Craven R, et al. Obesity is associated with worse overall survival in women with low-grade papillary serous epithelial ovarian cancer. Int J Gynecol Cancer. 2014;24(4):670- 675. doi:10.1097/IGC.0000000000000109.
  7. Jessmon P, Boulanger T, Zhou W, Patwardhan P. Epidemiology and treatment patterns of epithelial ovarian cancer. Expert Rev Anticancer Ther. 2017;17(5):427-437. doi:10.1080/14737140.2017.1299575.
  8. National Collaborating Centre for Cancer. National Institute for Health and Clinical Excellence: Guidance. Ovarian Cancer: The Recognition and Initial Management of Ovarian Cancer. Cardiff (UK): National Collaborating Centre for Cancer (UK); 2011.
  9. Ledermann JA, Raja FA, Fotopoulou C, Gonzalez-Martin A, Colombo N, Sessa C. Newly diagnosed and relapsed epithelial ovarian carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2013;24 Suppl 6:vi24-32. doi:10.1093/annonc/mdt333.
  10. Belkic K, Belkic D. The Challenge of Ovarian Cancer: Steps Toward Early Detection Through Advanced Signal Processing in Magnetic Resonance Spectroscopy. Isr Med Assoc J. 2017;19(8):517-525.
  11. Network NCC. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines): Ovarian cancer: including fallopian tube cancer and primary peritoneal cancer. Version 3. Washington, PA: National Comprehensive Cancer Network; 2014:19034.
  12. Bilgin T, Karabay A, Dolar E, Develioglu OH. Peritoneal tuberculosis with pelvic abdominal mass, ascites and elevated CA 125 mimicking advanced ovarian carcinoma: a series of 10 cases. Int J Gynecol Cancer. 2001;11(4):290-294. doi:10.1046/j.1525-1438.2001.011004290.x.
  13. de Waal YR, Thomas CM, Oei AL, Sweep FC, Massuger LF. Secondary ovarian malignancies: frequency, origin, and characteristics. Int J Gynecol Cancer. 2009;19(7):1160-1165. doi:10.1111/IGC.0b013e3181b33cce
  14. Dogan E, Altunyurt S, Altindag T, Onvural A. Tubo-ovarian abscess mimicking ovarian tumor in a sexually inactive girl. J Pediatr Adolesc Gynecol. 2004;17(5):351-352. doi:10.1016/j.jpag.2004.07.002.
  15. Kuppuvelumani P, Rachagan SP, Syed N, Kumar G, Cheah PL. Rare case of huge retroperitoneal liposarcoma presenting as a gynaecological problem. Eur J Obstet Gynecol Reprod Biol. 1993;48(3):220-222. doi:10.1016/0028-2243(93)90091-P.
  16. Mehra BR, Thawait AP, Gupta DO, Narang RR. Giant abdominal hydatid cyst masquerading as ovarian malignancy. Singapore Med J. 2007;48(11):e284-286.
  17. Monterroso V, Jaffe ES, Merino MJ, Medeiros LJ. Malignant lymphomas involving the ovary. A clinicopathologic analysis of 39 cases. Am J Surg Pathol. 1993;17(2):154-170. doi:10.1097/00000478-199302000-00007.
  18. Oge T, Ozalp SS, Yalcin OT, et al. Peritoneal tuberculosis mimicking ovarian cancer. Eur J Obstet Gynecol Reprod Biol. 2012;162(1):105-108. doi:10.1016/j.ejogrb.2012.02.010.
International Journal of Travel Medicine and Global Health
Volume 6, Issue 3 - Serial Number 22
September 2018
Pages 121-124

Files

History

  • Receive Date: 07 May 2018
  • Revise Date: 21 September 2018
  • Accept Date: 21 September 2018

Share

How to cite

Statistics