International Travel Medicine Center of Iran International Journal of Travel Medicine and Global Health 2322-1100 13 4 2025 12 01 A Comprehensive Review of Statins' Dual Role in Alzheimer's Disease 253 263 224909 10.30491/ijtmgh.2025.522895.1479 EN Seyed Mohammad Afarin Student research committee, Baqiyatallah University of Medical Sciences, Tehran, Iran Gholamreza Poorheidari Department of Pharmacology and Toxicology, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran Mahdi Mashhadi Akbar Boojar Department of Pharmacology and Toxicology, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran 0000-0002-2002-9332 Journal Article 2025 05 11 Aims: Alzheimer's disease (AD), the primary cause of dementia, affects millions. Statins, used for cholesterol lowering, may have a dual role in AD development and treatment, potentially offering neuroprotection but with unclear clinical outcomes and heterogeneous data. This review assesses statins' role, cognitive effects, therapeutic uses, and limitations in AD.<br>Materials and Methods: A systematic search of PubMed, Scopus, and Google Scholar (1995–2024) using MeSH keywords) Alzheimer's Disease, Cognition disorders, Dementia, Memory impairment, Neurodegenerative diseases, Statins( identified 268 articles, refined to 98 based on relevance and quality. Studies included primary and secondary research on statins’ cognitive effects.<br>Results: Evidence on statins’ cognitive impact in AD is mixed. Some studies suggest benefits through reduced beta-amyloid (Aβ) production and anti-inflammatory effects, particularly in ApoE4 carriers or early-stage AD, while others report reversible cognitive impairment, especially with lipophilic statins. Observational studies show conflicting results compared to randomized controlled trials (RCTs), with limitations in study design and dosage variability. Statins therapy is recommended for AD patients with metabolic disorders.<br>Conclusion: Statins’ cholesterol-lowering, anti-inflammatory, and antioxidant properties offer potential neuroprotection, but their impact on AD pathology remains unclear due to heterogeneous data and unexamined dose-response relationships. Long-term RCTs with stratified patient groups (e.g., by statin type, disease stage, or ethnicity) are needed to clarify efficacy and risks. https://www.ijtmgh.com/article_224909_78704f5b46f9a623baf6d66856564cdf.pdf