International Travel Medicine Center of Iran International Journal of Travel Medicine and Global Health 2322-1100 14 3 2026 09 01 Gastrointestinal Cancers: The Impact of Gut Prebiotics 147 152 247026 10.30491/ijtmgh.2025.507687.1463 EN Mohammad Mehdipour Comprehensive Health Research Center, Bab.C., Islamic Azad University, Babol, Iran. 0009-0005-4794-2040 Aref Madady Comprehensive Health Research Center, Bab.C., Islamic Azad University, Babol, Iran. 0009-0005-9211-2433 Nika Jookesht Comprehensive Health Research Center, Bab.C., Islamic Azad University, Babol, Iran. 0009-0005-0399-9547 Mohammadreza Shabanpour Comprehensive Health Research Center, Bab.C., Islamic Azad University, Babol, Iran. 0009-0008-7759-0164 Fahimeh Hajizade Comprehensive Health Research Center, Bab.C., Islamic Azad University, Babol, Iran. 0009-0000-4894-3794 Mahdieh Ebrahimi Comprehensive Health Research Center, Bab.C., Islamic Azad University, Babol, Iran. 0009-0007-9739-303X Sepideh Mokabberi Comprehensive Health Research Center, Bab.C., Islamic Azad University, Babol, Iran. 0009-0003-6068-9110 Journal Article 2025 02 19 Gastrointestinal cancers, including those of the esophagus, stomach, and colon, represent a significant global health challenge with high morbidity and mortality rates. Recent research has highlighted the potential role of gut prebiotics in influencing cancer development and progression. This review examines the mechanisms by which prebiotics, non-digestible fibers that promote the growth of beneficial gut bacteria, may contribute to gastrointestinal health and cancer prevention. We explore the impact of prebiotics on gut microbiota composition, immune modulation, and the production of short-chain fatty acids (SCFAs), which have been associated with anti-inflammatory and anticancer properties. Additionally, we discuss emerging evidence from clinical and preclinical studies that suggest a protective effect of prebiotics against gastrointestinal cancers. By synthesizing current findings, this review aims to underscore the importance of dietary interventions utilizing prebiotics as a potential strategy for reducing the risk of gastrointestinal cancers and improving patient outcomes. Future research directions are proposed to further investigate the clinical implications and optimal application of prebiotics in cancer prevention and management. https://www.ijtmgh.com/article_247026_4d151b3fff5d1dba6f523bd1bb46fdb1.pdf