International Travel Medicine Center of Iran International Journal of Travel Medicine and Global Health 2322-1100 3 1 2015 02 01 Can Viral Load Predict Liver Histology in Patients With Chronic Hepatitis B? 19 21 33162 10.20286/ijtmgh-030119 EN Ashraf Karbasi Baqiyatallah Research Center of Gastroenterology and Liver Disease, Baqiyatallah University of Medical Sciences, Tehran, Iran Behzad Bafandeh Baqiyatallah Research Center of Gastroenterology and Liver Disease, Baqiyatallah University of Medical Sciences, Tehran, Iran Seyed-Moayed Alavian Baqiyatallah Research Center of Gastroenterology and Liver Disease, Baqiyatallah University of Medical Sciences, Tehran, Iran Amin Saburi Chemical Injury Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran 0000-0001-7743-8244 Journal Article 2014 09 07 <strong>Introduction:</strong> Hepatitis B virus (HBV) infection is a global public health problem. Serum HBV DNA measurement is a non-invasive test that predicts the liver disease progression. The aim of this study was to determine the HBV DNA level and look for a relation between the HBV DNA level and liver histology. <br/><strong>Methods:</strong> This was a cross sectional study on chronic hepatitis B infected patients in Tehran Hepatitis Center from 2006 to 2010. Percutaneus liver biopsy was performed in all patients. Patients with a history of any treatment and co-infection of HCV, HDV and HIV were excluded. <br/><strong>Results:</strong> 301 patients were included in this study. The mean age was 34.63±13.25 years. Mean serum HBV DNA level was 1.35* 108 ± 10.5*109 copies/ml.  Mean inflammatory score (grade) was 5.54±3.26 and fibrosis (stage) was 1.93±1.56. There wasn’t any significant relation between age and sex with liver histology. No significant relation was seen between liver histology and the HBV DNA level. HBe Ag positive patients had a higher serum HBV DNA level. <br/><strong>Conclusion: </strong>There wasn’t any significant relation between liver histology and the HBV DNA level. We suggest using liver biopsy as a golden standard. In addition we need more studies in this field. https://www.ijtmgh.com/article_33162_30fb29ade62fcc64db06d1001676c913.pdf