International Travel Medicine Center of IranInternational Journal of Travel Medicine and Global Health2322-110013120250301Role of type II macrophages in the treatment of pulmonary inflammations121621158410.30491/ijtmgh.2024.468329.1421ENHoseinRahmaniStudent Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran.ShabnamBahramiApplied Virology Research Center, Biomedicine Technologies Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.AlirezaShahriaryChemical Injuries Research Center, Systems biology and poisonings institute, Baqiyatallah University of Medical Sciences, Tehran, IranHadiEsmaeili GouvarchinghalehApplied Virology Research Center, Biomedicine Technologies Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.BahmanJalali KondoriBaqiyatallah Research Center for Gastroenterology and Liver Diseases (BRCGL), Baqiyatallah University of Medical Sciences, Tehran, Iran.AmirhosseinMaghariBaqiyatallah University of Medical Sciences, Tehran, Iran.MostafaGhaneiChemical Injuries Research Center, Systems biology and poisonings institute, Baqiyatallah University of Medical Sciences, Tehran, IranJournal Article20240720Pneumonia is a common acute respiratory infection that affects the alveoli and distal airways; it is a major health problem and associated with high morbidity and short-term and long-term mortality in all age groups worldwide. Pneumonia is broadly divided into community-acquired pneumonia or hospital-acquired pneumonia. A large variety of microorganisms can cause pneumonia, including bacteria, respiratory viruses and fungi, and there are great geographical variations in their prevalence. Pneumonia occurs more commonly in susceptible individuals,including children of <5 years of age and older adults with prior chronic conditions. Development of the disease largely depends on the host immune response,with pathogen characteristics having a less prominent role. Individuals with pneumonia often present with respiratory and systemic symptoms, and diagnosis is based on both clinical presentation and radiological findings. It is crucial to identify the causative pathogens, as delayed and inadequate antimicrobial therapy can lead to poor outcomes.New antibiotic and non-antibiotic therapies,in addition to rapid and accurate diagnostic tests that can detect pathogens and antibiotic resistance will improve the management of pneumonia. Macrophages represent the first line of anti-pathogen defense. they encounter invading pathogens to perform the phagocytic activity, to deliver the plethora of pro- and anti-inflammatory cytokines, and to shape the tissue microenvironment. Throughout pneumonia course, alveolar macrophages and infiltrated blood monocytes produce increasing cytokine amounts, which activates the antiviral/antibacterial immunity but can also provoke the risk of the so-called cytokine “storm” and normal tissue damage. The aim of this study is to investigate the effect of macrophages on lung inflammation.https://www.ijtmgh.com/article_211584_fd36342c1fe6cdb8ff6ff244c9738fb6.pdfInternational Travel Medicine Center of IranInternational Journal of Travel Medicine and Global Health2322-110013120250301The impact of traveling on infectious diseases transmission with a focus on air travel: A Narrative Review334120968410.30491/ijtmgh.2024.485399.1439ENSeyed KiarashAghayanDepartment of Veterinary Medicine, Shabestar Branch, Islamic Azad University, Shabestar, Iran0000-0002-8165-1344FazelMoghadas HosseinzadehDepartment of Microbiology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.Journal Article20241028The global tourism industry has experienced significant growth from 2009 to 2014, with international tourist arrivals increasing from 25.3 million in 1950 to 1.138 billion in 2014. This surge in travel, projected to grow at an annual rate of 6%, has implications for public health, particularly concerning the spread of infectious diseases. Travelers can act as carriers of pathogens, introducing them to new regions, often without showing symptoms. EIDs pose a considerable threat, exacerbated by increased global mobility and urbanization. Air travel, in particular, has facilitated the rapid transmission of diseases like SARS and influenza, highlighting the need for effective public health measures to mitigate risks. The interconnectedness of travel networks and infectious disease dynamics is evident, as pathogens can be transported across vast distances, leading to outbreaks in previously unaffected areas. Factors influencing disease transmission include human demographics, environmental changes, and technological advancements. The introduction of pathogens into new populations can lead to outbreaks, especially when immunity is lacking. Understanding the interplay between human mobility and infectious disease transmission is crucial for developing strategies to prevent and control outbreaks in an increasingly mobile world.https://www.ijtmgh.com/article_209684_f3f378f379b677ce385271a62ce22230.pdfInternational Travel Medicine Center of IranInternational Journal of Travel Medicine and Global Health2322-110013120250301The Evaluation for the incidence of fragility fracture in osteoporotic patients in comparison to osteopenia patients425021101210.30491/ijtmgh.2024.489613.1443ENAliMokhberStudents Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran.NoushinBayatDepartment of Rheumatology, Exercise Physiology Research Center, Lifestyle Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.GholamhosseinAlishiriChemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.Seyed KiarashAghayanApplied Virology Research Center, Biomedicine Technologies Institute, Baqiyatallah University of Medical sciences, Tehran, Iran.0000-0002-8165-1344SorayaShadmanfarDepartment of Rheumatology, Exercise Physiology Research Center, Lifestyle Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.0000-0003-4672-6096RezaMohtashamiMedicine, Quran, and Hadith Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.0000-0002-4087-6061Journal Article20241119Introduction: Osteoporosis is a serious metabolic bone disorder marked by thinning and brittle bones, predominantly affecting elderly individuals, especially postmenopausal women. The purpose of this cohort study is to investigate the frequency of fractures caused by bone fragility in osteoporotic patients compared to osteopenia patients.<br />Method: This study included men and women aged 20-90 from Baqiyatallah Hospital's rheumatology clinic. Patients' osteoporosis database information was collected, along with demographic and clinical data, including medical history, drug use, and family history. Patients were classified into osteoporosis and osteopenia groups based on bone density measurements. General biomarker tests related to bone metabolism were conducted.<br />Results: In this study, 1264 (76.4%) had osteopenia, while 390 (23.6%) had osteoporosis. Significant differences were found in age, receiving thyroid medication, and various health conditions between the two groups. Major osteoporotic index and hip fracture index were higher in the osteopenia group, while Young-Femur and age-Femur indices were lower. Various blood indices differed significantly between the two groups. Vitamin D3 levels were higher in the osteopenia group, while alkaline phosphatase levels were lower. Factors such as thyroid medication, underactive thyroid, liver disorders, Young-Femur variables, HB, HCT, RBC, and vitamin D3 were associated with higher chances of osteopenia. Conversely, kidney disease, epilepsy, dietary nutrient intake, major osteoporotic indices, hip fracture index, WBC, BUN, Crea, ESR, alkaline phosphatase, and age were linked to higher chances of osteoporosis.<br />Conclusion: Understanding fracture frequency in osteoporotic and osteopenia patients, along with related risk factors, aids in prevention planning.https://www.ijtmgh.com/article_211012_a683af51b9a1f7a54d2647c6954ab509.pdfInternational Travel Medicine Center of IranInternational Journal of Travel Medicine and Global Health2322-110013120250301Investigating the antimicrobial and anti-adhesion properties of the alcoholic extract of Verbascum sinuatum plant on the biofilm formation of three intestinal bacteria243221158110.30491/ijtmgh.2024.482328.1437ENFatemehSeyed SiahiDepartment of Microbiology, Bonab Branch, Islamic Azad University, Bonab, Iran.ZahraHojjati BonabDepartment of Microbiology, Bonab Branch, Islamic Azad University, Bonab, Iran.Journal Article20241007Introduction: Intestinal bacteria enter the body through contaminated food and water or contact with infected people and animals. These bacteria cause blood, urine, bone or nervous system infections in humans. The most important bacteria that cause these diseases include Salmonella typhimurium, Klebsiella pneumoniae and Shigella sonnei. The increasing drug resistance of bacteria created the necessity of investigating the antibacterial effects of Verbascum sinuatum plant extract on the planktonic form and biofilm of all three bacteria in question.<br />Material and methods: After preparing and cultivating standard bacteria and preparing biofilm from three intestinal bacteria, the effect of alcoholic extract of V.sinuatum on planktonic bacteria and the biofilm caused by them was investigated by well plate method. The value of minimum inhibitory concentration (MIC) and minimum bacteriocidal concenteration (MBC) was determined on planktonic form and biofilm of bacteria.<br />Results: results showed that the alcoholic extract of V.sinuatum has antimicrobial effect on Salmonella typhimurium and Klebsiella pneumoniae. V.sinuatum also has inhibitory effect and has antimicrobial effect on the biofilm of Salmonella typhimurium and Klebsiella pneumoniae.<br />Conclusion: The formation of biofilm is an important factor in stability and as a result, it is the cause of infections that are difficult to deal with. Klebsiella pneumoniae and Salmonella typhimurium also have the ability to form biofilm and it is considered an important cause of many infections, so it is important to fight this infectious factor using the extract of V.sinuatum plant.https://www.ijtmgh.com/article_211581_10462edd391dad40a2c9b78a7f1eb087.pdfInternational Travel Medicine Center of IranInternational Journal of Travel Medicine and Global Health2322-110013120250301Evaluation of Clinical and Laboratory data of COVID-19 Patients in Comparison with CT Scan Findings172321158210.30491/ijtmgh.2024.481229.1435ENRaminBazvandStudent Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran.SoleimanHeidariTrauma Research Center, Clinical sciences institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.RamazanJafariDepartment of Radiology, Health Research Center, Lifestyle Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.AliZahiriStudent Research Committee, Baqiyatallah University of Medical Sciences, Tehran, IranHasanGoodarziTrauma Research Center, Clinical sciences institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.Journal Article20240930Introduction: In order to better evaluate the coronavirus disease, examination of laboratory, radiological and clinical findings can help the researcher to treatment of COVID-19 Patients. This study aimed to highlight the evaluation of clinical and laboratory data of covid-19 patients in comparison with CT scan findings<br />Materials and Methods: This retrospective study was performed on COVID-19 patients admitted to Baqiyatallah Hospital in Tehran (Iran) in 2019. In this study, laboratory findings, CT scan, clinical signs, comorbidity and its changes were examined.<br />Results: This study was performed on 400 patients (265 males and 135 females) covid-19 patients. In this study, the variables of age, CRP, POLY, CR and RBC on the length of hospital stay and also the variables of age, oxygen saturation, POLY, LYMPH, RBC, BUN, Ca, Mg and AST significant affect the death of patients.<br />Conclusion: According to the results of this study, it is recommended to measure the laboratory variables CRP, POLY, RBC, LYMPH, BUN, ESR, and WBC and to study the trend of changing these variables to predict death and length of hospital stay of patients with COVID-19.https://www.ijtmgh.com/article_211582_65017e1f28f36531e55c01cc767099be.pdfInternational Travel Medicine Center of IranInternational Journal of Travel Medicine and Global Health2322-110013120250301Frequency and Factors Associated with Symptomatic Urinary Tract Infection in Catheterized Male Patients: A Single Centre Case-Control Study11121158310.30491/ijtmgh.2024.467880.1420ENTagang TitusNgwa-EbogoDepartment of Clinical Sciences, Faculty of Health Sciences, The University of Bamenda, Bamenda, Cameroon0000-0002-2590-0246ANOUBOWEH LESLIEFORLEMUDepartment of Medicine, Mutengene Baptist Hospital, Mutengene, CameroonLandry OrioleMboucheFaculty of Medicine and Biomedical Sciences, University of Yaounde, Yaounde, Cameroon0000-0002-6838-4106NdiforJudethaddeusDepartment of Surgery, Regional Hospital Bamenda, Bamenda, CameroonCHIEDJIO ArielleNGONGANGDepartment of Medicine, Baptist Hospital Mutengene, Mutengene, CameroonAchillei AurèleMbassDepartment of Surgery and Specialties, Institut Supérieur de Technologie Médicale Nkolondom, Yaounde, CameroonMarie LouiseManka'aMD Research Group, Bamenda, CameroonGloria ENOWASHUTANTANGDepartment of Clinical Sciences, Faculty of Health Sciences, The University of Bamenda, Bamenda, CameroonFru FobuzshiAngwafo IIIDepartment of Surgery, Regional Hospital Bamenda, Bamenda, Cameroon0000-0003-3237-4237Journal Article20240715Introduction: Catheter-Associated Urinary Tract Infections (CA-UTI) are a significant cause of morbidity and mortality in hospitalized patients. This study investigates the prevalence, aetiology, and risk factors associated with CA-UTI in male patients at a referral hospital in North West Cameroon.<br />Methods: A hospital-based cross-sectional study was conducted from March 1, 2022, to June 30, 2022, at the Nkwen Baptist Hospital. Male patients catheterized for bladder outlet obstruction (BOO) for at least two days were included. Data were collected using structured questionnaires and analysed with Python. Multivariate logistic regression identified independent predictors of CA-UTI.<br />Results: Out of 72 participants, 16 (22.2%) had CA-UTI. Significant risk factors included older age (OR = 1.086, p = 0.017), smoking (OR = 4.25, p < 0.001), diabetes (OR = 7.31, p < 0.001), HIV (OR = 5.87, p < 0.001), chronic kidney disease (CKD) (OR = 9.84, p < 0.001), malignancy (OR = 3.28, p = 0.015), and the use of latex catheters (OR = 2.57, p = 0.048). Shorter duration of catheter dependency also increased CA-UTI risk (OR = 0.020, p = 0.001).<br />Conclusion: The prevalence of CA-UTI was 22.2% among the study population. Significant associations were found with age, smoking, diabetes, HIV, CKD, malignancy, and latex catheter use. These findings highlight the need for targeted interventions to manage these risk factors and reduce CA-UTI incidence in clinical settings. Effective infection control practices, patient education, and risk factor management are essential for mitigating CA-UTI.https://www.ijtmgh.com/article_211583_f6033ebc4ccb89e8ab77ddc8d6a53283.pdfInternational Travel Medicine Center of IranInternational Journal of Travel Medicine and Global Health2322-110013120250301The Role of Life Satisfaction, Tolerance for Ambiguity, Perfectionism, And Demographic Characteristics in Predicting Students' Propensity to Migrate515821252510.30491/ijtmgh.2025.492768.1445ENToktamKazemi LariDepartment of Psychology, Shiraz Branch, Islamic Azad University, Shiraz, Iran0000-0002-3414-6716FarzanehHoomanDepartment of Psychology, Shiraz Branch, Islamic Azad University, Shiraz, Iran0000-0002-9706-7740Journal Article20241207Introduction: Increased globalization and interconnectedness have led to greater student mobility, making it crucial to understand the factors influencing students' decisions to migrate for educational or professional opportunities. This research aimed to investigate the correlational interplay between life satisfaction, tolerance for ambiguity, perfectionism, and demographic characteristics in predicting students’ migration intention.<br />Methods: The research employed a descriptive correlational design. The population comprised all students enrolled at Islamic Azad University, Shiraz Branch in 2023. A convenience sample of 260 students was selected. Data were collected using the Migration Intention Questionnaire, Satisfaction with Life Scale, Ambiguity Tolerance Scale, and Positive and Negative Perfectionism Scale. Additionally, students' gender and income were examined as demographic characteristics. For data analysis, point-biserial correlation and discriminant analysis were utilized.<br />Results: The findings revealed a significant negative correlation between life satisfaction and migration intention, and a significant positive correlation between tolerance for ambiguity and migration intention (P<0.001). A significant positive correlation was also observed between positive perfectionism and migration intention. Income was also positively and significantly associated with migration intention (P<0.001). Furthermore, discriminant analysis identified only life satisfaction and income as significant predictors of migration intention (P<0.001). No significant relationships were found between negative perfectionism and migration intention, or between gender and migration intention.<br />Conclusion: The study found that life satisfaction and income are significant predictors of students' migration intention, while tolerance for ambiguity and positive perfectionism also play a role. However, negative perfectionism and gender were not found to be significant factors in predicting migration intention.https://www.ijtmgh.com/article_212525_340b9e97ec2268e6477ea160ab6a0ca5.pdfInternational Travel Medicine Center of IranInternational Journal of Travel Medicine and Global Health2322-110013120250301An Overview of Diseases Related to Homosexuality People596921299110.30491/ijtmgh.2024.493102.1446ENNargesVahidniyaDepartment of Education and Counseling, Faculty of Psychology and Educational Sciences, Islamic Azad University, Central Branch, Tehran, Iran0000-0001-7547-8269Journal Article20241209Homosexual individuals face significantly higher rates of mental health issues and suicidal tendencies than their heterosexual counterparts. Homosexual individuals face a greater risk of developing cancers, contracting sexually transmitted infections (STIs), acquiring Human immunodeficiency virus (HIV), as well as experiencing mental health disorders when compared to their heterosexual counterparts. Early detection and treatment of anal sexually transmitted infections in homosexual men can greatly enhance HIV prevention efforts and ultimately save lives. This result emphasizes the critical importance of routine STI testing for HIV-positive men to safeguard their health and significantly lower the risk of ongoing HIV transmission. Homosexual men often engage in high-risk sexual behaviors and injection practices, significantly increasing their vulnerability to contracting and spreading HIV and other infectious diseases. Recognizing and addressing these risks is crucial to promote public health and safety. Homosexual individuals are at higher risk of mental disorders than heterosexual individuals. This study highlights vital avenues for future research and underscores the significant implications for public policy.https://www.ijtmgh.com/article_212991_84f250396ed1ce34862613b977cdfccc.pdfInternational Travel Medicine Center of IranInternational Journal of Travel Medicine and Global Health2322-110013120250301A Study on the Correlation between Annual Noise Exposure (ANE) and Auditory Attention, as well as Hearing Loss in Military Personnel22135610.30491/ijtmgh.2025.525090.1483ENSeyed HojatMousavi KordmiriHealth Research Center, Lifestyle Institute, Baqiyatallah University of Medical Sciences, Tehran, IranSajjadSamieiHealth Research Center, Lifestyle Institute, Baqiyatallah University of Medical Sciences, Tehran, IranFatemehRahmatiHealth Research Center, Lifestyle Institute, Baqiyatallah University of Medical Sciences, Tehran, IranMohammadGhasemiHealth Research Center, Lifestyle Institute, Baqiyatallah University of Medical Sciences, Tehran, IranJournal Article20241023There are various types of noise-generating equipment in the living and working environment of military personnel, which causes auditory and non auditory health problems. In order to assessment of occupational and non occupational noise exposure this study was conducted to investigate the validity and reliability of the Persian version of the noise exposure questionnaire (NEQ) as a unique quantitative tool and also its relationship with auditory attention and hearing loss among military personnel. The results of quantitative face validity, consistency and reproducibility of this questionnaire were confirmed the utility of NEQ as a quick tool to assess the annual noise exposure occupationally and Nonoccupational (routine/occasional). In addition, a direct and significant relationship has been observed between the annual exposure of workers to noise and the increase in hearing threshold in all the investigated frequencies.https://www.ijtmgh.com/article_221356_d05631a3ab6628f68f62609b1bb0babf.pdfInternational Travel Medicine Center of IranInternational Journal of Travel Medicine and Global Health2322-110013120250301Designing an Immunoinformatics Vaccine Based on Epitopes Against Human Papillomavirus: One of the Novel Methods to Replace Laboratory Animals22158010.30491/ijtmgh.2025.525344.1484ENAliNajafiMolecular Biology Research Center, Biomedicine Technologies Institute, Baqiyatallah University of Medical Sciences, Tehran, IranSeyed KiarashAghayanApplied Virology Research Center, Biomedicine Technologies Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran0000-0002-8165-1344SaeidAlizadeh LanganApplied Virology Research Center, Biomedicine Technologies Institute, Baqiyatallah University of Medical Sciences, Tehran, IranHadiEsmaeili Gouvarchin GhalehApplied Virology Research Center, Biomedicine Technologies Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran0000-0001-8562-2295Journal Article20241005The human papillomavirus (HPV) is the most common sexually transmitted viral infection, with low-risk types causing genital warts and high-risk types, particularly HPV 16, 18, 31 and 45 leading to cervical cancer. This study designed a vaccine targeting the E6 and E7 oncoproteins of HPV 16, 18, 31, and 45, utilizing a TLR4 agonist as an adjuvant. Simulations indicate that this vaccine can have preventive and therapeutic effects against HPV infection and cervical cancer. This new vaccine may aid in the design of vaccines against other viral sexually transmitted diseases.https://www.ijtmgh.com/article_221580_0b84017a2dffd1c1247da566f7c0f469.pdfInternational Travel Medicine Center of IranInternational Journal of Travel Medicine and Global Health2322-110013120250301Oncolytic Bacteria and Viruses: A Novel Approach for the Treatment of Colorectal Cancer22159610.30491/ijtmgh.2025.525539.1486ENMortezaIzadiHealth Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, IranJournal Article20241008This study investigates the effect of mesenchymal stem cells (MSCs) carrying Newcastle oncolytic virus, treated with the probiotic Lactobacillus casei, in the treatment of colorectal cancer in a mouse model. Colorectal cancer is a significant health issue and the third leading cause of death worldwide. The results showed that mice receiving MSCs carrying the virus had better survival rates and slower tumor growth compared to the control group. Additionally, this treatment increased nitric oxide and IFN-γ production while decreasing IL-4, IL-10, and TGF-β secretion. However, treatment with Lactobacillus casei extract did not show a significant difference compared to the untreated group. The overall conclusion is that using MSCs carrying Newcastle oncolytic virus is beneficial in treating colorectal cancer.https://www.ijtmgh.com/article_221596_877701a75748cef96516ea1353505152.pdfInternational Travel Medicine Center of IranInternational Journal of Travel Medicine and Global Health2322-110013120250301Macrophages type 2 as candidates for the treatment of lung injuries22223210.30491/ijtmgh.2025.527814.1490ENAlirezaShahriaryChemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, IranMostafaEslami MahmoudabadiStudent Research Committee, Baqiyatallah University of Medical Sciences, Tehran, IranAlirezaNikkhahStudent Research Committee, Baqiyatallah University of Medical Sciences, Tehran, IranJournal Article20241018Sulfur mustard (SM) is a toxic chemical warfare agent that causes severe and persistent pulmonary damage, for which no specific treatment exists. Emerging evidence suggests that mesenchymal stem cells (MSCs) exert anti-inflammatory effects through paracrine signaling. This study evaluated the therapeutic potential of monocytes treated with MSC-derived supernatant in a murine model of SM-induced lung inflammation using CEES as a surrogate. Monocytes treated with MSC supernatant showed significant immunomodulatory effects, including reduced pro-inflammatory cytokines (IL-12), increased anti-inflammatory cytokines (IL-4, IL-10, TGF-β), and decreased oxidative stress markers (NO, MPO). Histopathological analysis revealed reduced inflammation, mucus accumulation, and tissue remodeling in treated animals. These findings suggest that MSC supernatant-treated monocytes may offer a novel therapeutic strategy for chemical-induced lung injury, warranting further investigation into their mechanisms and efficacy in more complex models.https://www.ijtmgh.com/article_222232_4750a0f966079c410a027e4a15aa4512.pdfInternational Travel Medicine Center of IranInternational Journal of Travel Medicine and Global Health2322-110013120250301Overcoming the Limitations of Oncolytic Therapy with Cell Carriers22159910.30491/ijtmgh.2025.525477.1485ENAmirYousefkhanyDepartment of Veterinary Medicine, Shabestar Branch, Islamic Azad University, Shabestar, IranSeyed KiarashAghayanApplied Virology Research Center, Biomedicine Technologies Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran0000-0002-8165-1344MahdiehFarzanehpourApplied Virology Research Center, Biomedicine Technologies Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran0000-0001-8562-2295Journal Article20240904Cancer is one of the biggest health challenges and the third leading cause of death worldwide. Cervical cancer, after breast cancer, is the most common type of cancer in women in many regions. Research has shown that oncolytic viruses, especially those that do not have humans as hosts, have significant anti-cancer effects. One of the challenges of using these viruses is their rapid clearance by the immune system. Therefore, the use of suitable carriers with anti-tumor affinity for delivering these viruses and enhancing their efficacy is essential. The aim of this study is to investigate the therapeutic effects of dendritic cells carrying Newcastle disease virus on the treatment of a mouse model of cervical cancer induced by papillomavirus. This study was conducted under cell culture conditions and mouse modeling. Forty female C57BL/6 mice weighing 20 to 25 grams and aged 6 to 8 weeks were divided into four groups. The groups included mice that were treated with PBS, doxorubicin, dendritic cells with tumor lysate, and dendritic cells carrying Newcastle disease virus, respectively. After observing palpable tumors, the mice were treated with virus-carrying dendritic cells. The results showed that mice receiving virus-carrying dendritic cells had better survival and slower tumor growth compared to the control group. Additionally, this treatment significantly increased nitric oxide and lactate dehydrogenase production while elevating IFN-γ secretion and reducing IL-4, IL-10, and TGF-β secretion.https://www.ijtmgh.com/article_221599_c5649413c683d4e80b49328eac8c421b.pdfInternational Travel Medicine Center of IranInternational Journal of Travel Medicine and Global Health2322-110013120250301Pistacia atlantica as an Alternative Source for Anti-Inflammatory Drugs22160410.30491/ijtmgh.2025.525729.1487ENMajidMirzaei NodooshanApplied Virology Research Center, Biomedicine Technologies Institute, Baqiyatallah University of Medical Sciences, Tehran, IranJournal Article20241022Inflammation is a natural immune system response characterized by increased blood flow and vascular permeability. In this study, 50 mice were divided into 5 groups, and after inducing inflammation, the levels of inflammatory and anti-inflammatory cytokines, antioxidant enzymes, and oxidative stress were measured. The results showed that the gum extract of the Pistacia atlantica significantly reduced the levels of inflammatory cytokines and oxidative stress while increasing the levels of antioxidant enzymes and anti-inflammatory cytokines. Therefore, the gum extract of the Pistacia atlantica plant may be considered as a natural compound with anti-inflammatory properties for the treatment of immunological disorders caused by inflammation.https://www.ijtmgh.com/article_221604_df2f49042765c2efcdfe43b82bb1642f.pdfInternational Travel Medicine Center of IranInternational Journal of Travel Medicine and Global Health2322-110013120250301Phage Therapy: A Novel Approach to Overcome Antibiotic Resistance22164410.30491/ijtmgh.2025.525734.1488ENRuhollahDorostkarApplied Virology Research Center, Biomedicine Technologies Institute, Baqiyatallah University of Medical Sciences, Tehran, IranJournal Article20240928In this study, the focus was on Pseudomonas aeruginosa, a common bacterial agent in keratitis that exhibits antibiotic resistance. The aim was to isolate, identify, and assess the antimicrobial potential of a bacteriophage sample for treating keratitis caused by P. aeruginosa. The bacteriophage was isolated from wastewater at Baqiyatallah Hospital in Tehran, Iran, and identified using TEM imaging. Various methods, including plaque assays and host range determination, were employed to confirm the presence of the phage. The study evaluated the phage's minimum inhibitory concentration (MIC), biofilm degradation, cytotoxicity, and the safety of phage-containing eye drops on New Zealand rabbits, as well as their effectiveness in a mouse model. The results indicated that the isolated phage belonged to the Myoviridae family and exhibited anti-biofilm activity against clinical isolates. The MIC and IC50 values for the phage were determined to be 10-8 and 10-1, respectively. Notably, the combination treatment of ciprofloxacin eye drops with phage drops proved more effective in improving keratitis than either treatment alone. In conclusion, while the therapeutic effect of the isolated phage on clinical strains of P. aeruginosa was demonstrated, the combination of antibiotic and phage treatment showed synergistic effects.https://www.ijtmgh.com/article_221644_3f6fd29849243f026a239ef120bcdeea.pdfInternational Travel Medicine Center of IranInternational Journal of Travel Medicine and Global Health2322-110013120250301Pistacia atlantica gum and ulcerative colitis: From hypothesis to reality22223110.30491/ijtmgh.2025.527812.1489ENEbrahimSalimi-SabourDepartment of Pharmacognosy and Traditional Pharmacy, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, IranAlirezaNikkhahStudent Research Committee, Baqiyatallah University of Medical Sciences, Tehran, IranMostafaEslami MahmoudabadiStudent Research Committee, Baqiyatallah University of Medical Sciences, Tehran, IranJournal Article20240917Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD) characterized by secretory and motility dysfunctions of the intestinal tract. Conventional pharmacological therapies are often associated with significant side effects and impose high costs on patients. In recent years, natural compounds have gained attention as complementary treatments. The present study aimed to investigate the therapeutic effects of Pistacia atlantica gum extract on histopathological and immunological markers in an experimental model of UC. The results demonstrated that Pistacia atlantica gum extract, administered either before or after disease induction, significantly reduced the levels of inflammatory mediators and cytokines compared to the positive control group. Overall, our findings suggest that Pistacia atlantica gum extract alleviates the symptoms of ulcerative colitis in this experimental model. It may serve as a promising complementary treatment option for UC patients; however, further molecular investigations are required to elucidate its mechanisms of action.https://www.ijtmgh.com/article_222231_d1b8bfaf8139e91aa7e9c6144056535c.pdfInternational Travel Medicine Center of IranInternational Journal of Travel Medicine and Global Health2322-110013120250301Management of rheumatoid arthritis disease activity criteria with the natural compound22491010.30491/ijtmgh.2025.532982.1499ENSamanBoostaniDepartment of Veterinary Medicine, Science and Research Branch. Islamic Azad University, Tehran, Iran0009-0000-6252-1272RezaMohtashamiMedicine, Quran, and Hadith Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran0000-0002-4087-6061Journal Article20250707Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation and systemic complications, driven by immune dysregulation and pro-inflammatory cytokines. This study evaluated the immunomodulatory effects of Peminine , a natural compound derived from Fritillaria imperialis, in a mouse model of collagen-induced arthritis. Results showed that Peminine significantly reduced paw swelling, inflammatory markers (RF, CRP), nitric oxide, and myeloperoxidase levels. It also suppressed pro-inflammatory cytokines IL-1 and TNF-α while increasing the anti-inflammatory cytokine IL-10. These effects were comparable to those of Prednisolone in several aspects. Peminine demonstrated strong anti-inflammatory and immunomodulatory properties, suggesting its potential as a complementary therapy for RA. Further clinical studies are needed to confirm these findings in humans.https://www.ijtmgh.com/article_224910_92a5cf198951aac031a25344b9859ea7.pdf