How Mobility of Resistance Determinants Affects the Dissemination of Antimicrobial Resistance?

Document Type : Review Article


Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria



Antibiotic resistance is primarily propagated by mobile genetic elements (MGEs) around the world. As a result, antibiotic resistance genes can be found in a wide spectrum of environmental microorganisms. Environmental bacteria are not resistant to all antibiotics now accessible, despite long histories of antibiotic development and exposure. As a result, obtaining a complete resistance arsenal will be challenging. The goal of this study is to look at how the mobility of resistance determinants influences antimicrobial resistance spread. The sources, distribution, and development of resistance mechanisms in various microorganisms and bacterial populations are mosaic features that act as barriers to the spread of bacterial pan-resistance. This is critical information for a better understanding of the genesis of resistance in hazardous bacteria, which could lead to improved antibiotic therapy and the creation of new medications.