A comprehensive review of Ebola virus: as a global health threat

Document Type : Review Article


1 Department of Cell Biology and Genetics, Bushehr Branch, Islamic Azad University, Bushehr, Iran.

2 Department of Industrial Management, Mehr Alborz Higher Education Institute, Tehran, Iran.

3 Faculty of Management, North Tehran Branch Islamic Azad University, Tehran, Iran.



The greatest Ebola virus disease (EVD) epidemic in recorded history is now occurring in West Africa. The Zaire Ebolavirus (EBOV), the virus responsible for this outbreak, is a member of the genus Ebolavirus, which combined with the genus Marburgvirus makes up the family of the Filoviridae. Among the viral hemorrhagic fevers, EBOV is one of the most aggressive viruses; case fatality rates of up to 90% have been documented. Multi-organ failure and serious bleeding problems are what cause death. The WHO recorded 5335 cases (confirmed, suspected, and probable) as of September 18th, 2014, with 2622 fatalities, yielding a case fatality rate of almost 50%. With a focus on pathophysiology, clinical symptoms, and therapeutic options, this review aims to provide an overview of EVD for clinicians.