Zoonotic diseases associated with sea travel pose a serious threat to public health due to increased international traffic and the movement of aquatic animals. These diseases, which are transmitted from animals to humans, are particularly complex because of the diversity of transmission routes and the absence of symptoms in many aquatic organisms. Risk factors include ecological changes, human demographic and behavioral characteristics, and the inefficiency of public health systems. Climate change and environmental degradation may lead to the emergence of new diseases in marine plants and animals. To prevent and control infectious diseases, multiple monitoring systems and control strategies have been designed by the WHO and WOAH. Public education and raising awareness among the medical community are key factors in the prevention and control of these diseases. Additionally, hand hygiene and the use of low-risk methods for greetings on cruise ships are recommended. Identifying transmission routes, assessing risks, and developing preventive strategies with a One Health approach are essential measures to combat these threats. However, research gaps and the lack of epidemiological data hinder the development of effective policies. The future of this field requires scientific investment and international collaboration to enhance preparedness against zoonotic diseases related to sea travel.