Designing an Immunoinformatics Vaccine Based on Epitopes Against Human Papillomavirus: One of the Novel Methods to Replace Laboratory Animals

Najafi, Ali; Aghayan, Seyed Kiarash; Alizadeh Langan, Saeid; Esmaeili Gouvarchin Ghaleh, Hadi

doi:10.30491/ijtmgh.2025.525344.1484

Designing an Immunoinformatics Vaccine Based on Epitopes Against Human Papillomavirus: One of the Novel Methods to Replace Laboratory Animals

Document Type : Policy Briefs

Authors

Ali Najafi ¹

Seyed Kiarash Aghayan ²

Saeid Alizadeh Langan ²

Hadi Esmaeili Gouvarchin ghaleh ²

¹ Molecular Biology Research Center, Biomedicine Technologies Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran

² Applied Virology Research Center, Biomedicine Technologies Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran

10.30491/ijtmgh.2025.525344.1484

Abstract

The human papillomavirus (HPV) is the most common sexually transmitted viral infection, with low-risk types causing genital warts and high-risk types, particularly HPV 16, 18, 31 and 45 leading to cervical cancer. This study designed a vaccine targeting the E6 and E7 oncoproteins of HPV 16, 18, 31, and 45, utilizing a TLR4 agonist as an adjuvant. Simulations indicate that this vaccine can have preventive and therapeutic effects against HPV infection and cervical cancer. This new vaccine may aid in the design of vaccines against other viral sexually transmitted diseases.

Keywords

Immunoinformatics

human papillomavirus

HPV

multi-epitope vaccine

TLR4

TLR9