This study investigates the effect of mesenchymal stem cells (MSCs) carrying Newcastle oncolytic virus, treated with the probiotic Lactobacillus casei, in the treatment of colorectal cancer in a mouse model. Colorectal cancer is a significant health issue and the third leading cause of death worldwide. The results showed that mice receiving MSCs carrying the virus had better survival rates and slower tumor growth compared to the control group. Additionally, this treatment increased nitric oxide and IFN-γ production while decreasing IL-4, IL-10, and TGF-β secretion. However, treatment with Lactobacillus casei extract did not show a significant difference compared to the untreated group. The overall conclusion is that using MSCs carrying Newcastle oncolytic virus is beneficial in treating colorectal cancer.
Izadi,M. (2025). Oncolytic Bacteria and Viruses: A Novel Approach for the Treatment of Colorectal Cancer. (e221596). International Journal of Travel Medicine and Global Health, 13(1), e221596 doi: 10.30491/ijtmgh.2025.525539.1486
MLA
Izadi,M. . "Oncolytic Bacteria and Viruses: A Novel Approach for the Treatment of Colorectal Cancer" .e221596 , International Journal of Travel Medicine and Global Health, 13, 1, 2025, e221596. doi: 10.30491/ijtmgh.2025.525539.1486
HARVARD
Izadi M. (2025). 'Oncolytic Bacteria and Viruses: A Novel Approach for the Treatment of Colorectal Cancer', International Journal of Travel Medicine and Global Health, 13(1), e221596. doi: 10.30491/ijtmgh.2025.525539.1486
CHICAGO
M. Izadi, "Oncolytic Bacteria and Viruses: A Novel Approach for the Treatment of Colorectal Cancer," International Journal of Travel Medicine and Global Health, 13 1 (2025): e221596, doi: 10.30491/ijtmgh.2025.525539.1486
VANCOUVER
Izadi M. Oncolytic Bacteria and Viruses: A Novel Approach for the Treatment of Colorectal Cancer. Int J Travel Med Glob Health, 2025; 13(1): e221596. doi: 10.30491/ijtmgh.2025.525539.1486
