Management of rheumatoid arthritis disease activity criteria with the natural compound

Boostani, Saman; Mohtashami, Reza

doi:10.30491/ijtmgh.2025.532982.1499

Management of rheumatoid arthritis disease activity criteria with the natural compound

Document Type : Policy Briefs

Authors

Saman Boostani ¹

Reza Mohtashami ²

¹ Department of Veterinary Medicine, Science and Research Branch. Islamic Azad University, Tehran, Iran

² Medicine, Quran, and Hadith Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

10.30491/ijtmgh.2025.532982.1499

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation and systemic complications, driven by immune dysregulation and pro-inflammatory cytokines. This study evaluated the immunomodulatory effects of Peminine , a natural compound derived from Fritillaria imperialis, in a mouse model of collagen-induced arthritis. Results showed that Peminine significantly reduced paw swelling, inflammatory markers (RF, CRP), nitric oxide, and myeloperoxidase levels. It also suppressed pro-inflammatory cytokines IL-1 and TNF-α while increasing the anti-inflammatory cytokine IL-10. These effects were comparable to those of Prednisolone in several aspects. Peminine demonstrated strong anti-inflammatory and immunomodulatory properties, suggesting its potential as a complementary therapy for RA. Further clinical studies are needed to confirm these findings in humans.

Keywords

Rheumatoid arthritis

Peminine

Pro-inflammatory cytokines

Immunomodulatory properties