International Journal of Travel Medicine and Global Health

International Journal of Travel Medicine and Global Health

Gastrointestinal Cancers: The Impact of Gut Prebiotics

Articles in Press

Document Type : Review Article

Authors
Mohammad Mehdipour 1
Aref Madady 1
Nika Jookesht 1
Mohammadreza Shabanpour 2
Fahimeh Hajizade 1
Mahdieh Ebrahimi 1
Sepideh Mokabberi 1
1 Department of Cellular& Molecular Biology, Comprehensive Health Research Center, Islamic Azad University, Babol Branch, Babol, Iran
2 Department of Microbiology, Comprehensive Health Research Center, Islamic Azad University, Babol Branch, Babol, Iran
10.30491/ijtmgh.2025.507687.1463
Abstract
Gastrointestinal cancers, including those of the esophagus, stomach, and colon, represent a significant global health challenge with high morbidity and mortality rates. Recent research has highlighted the potential role of gut prebiotics in influencing cancer development and progression. This review examines the mechanisms by which prebiotics, non-digestible fibers that promote the growth of beneficial gut bacteria, may contribute to gastrointestinal health and cancer prevention. We explore the impact of prebiotics on gut microbiota composition, immune modulation, and the production of short-chain fatty acids (SCFAs), which have been associated with anti-inflammatory and anticancer properties. Additionally, we discuss emerging evidence from clinical and preclinical studies that suggest a protective effect of prebiotics against gastrointestinal cancers. By synthesizing current findings, this review aims to underscore the importance of dietary interventions utilizing prebiotics as a potential strategy for reducing the risk of gastrointestinal cancers and improving patient outcomes. Future research directions are proposed to further investigate the clinical implications and optimal application of prebiotics in cancer prevention and management.
Keywords
Gastrointestinal cancers
Prebiotics
Gut microbiota
Cancer prevention
International Journal of Travel Medicine and Global Health

Articles in Press, Accepted Manuscript
Available Online from 11 July 2026

  • Receive Date 27 February 2025
  • Revise Date 04 April 2025
  • Accept Date 04 April 2025